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The kidneys present a large filtering surface to blood contents and are vulnerable to damage by circulating immune complexes (CIC). These complexes may increase when the digestive tract leaks large food molecules (mostly proteins) into the blood. Whatever comes in must go out. Our urinary system has the job of excreting unwanted, hazardous materials. If problems arise in this system, why should we not attempt to trace the problems back to body input?
The food-source of circulating immune complexes (CICs) has been neglected in clinical medicine. Doctors will often think of the most complicated, rare, outrageous things before they will think of the simple, obvious, daily intake of antigenic problems in the food supply! Transient kidney pain in the flanks signals the presence of CICs and often imitates an attack of kidney infection or renal colic. Mild, brief versions of this pain are common in people with delayed-pattern food allergy. In the worst case, patients with food allergy may have fever with flank pain and frequency of urination and are often thought to have kidney infection.
Glomerulonephritis is a serious form of kidney inflammation which may sometimes be triggered by CICs containing food protein antigens. Kidney inflammation may lead to hypertension and eventual kidney damage. The recurring triad of transient flank pain, blood or protein in the urine, and the presence of symptoms in other systems should suggest "food allergy" until proven otherwise.
Careful diet revision may show benefit in controlling kidney inflammation; A food holiday on Alpha ENF is especially useful in the beginning since all antigenic material is excluded. Patients with existing kidney disease benefit from a low protein diet and will also experience the least demand on diminishing kidney function with an ENF. Close professional supervision is always necessary with serious disease.
The nephrotic syndrome involves increased glomerular excretion of protein - Gabordi et al reported a 6 year old girl with gluten allergy expressed as celiac disease and dermatitis herpetiformis who developed nephrotic syndrome. Elimination of gluten grains resolved all three major manifestations of gluten allergy. Sandberg et al reported on 6 patients who experienced remission of nephrotic syndrome when milk was eliminated from their diet and exacerbation when it was reintroduced. Six patients in a study of 17 children with steroid resistant nephrotic syndrome responded to milk exclusion with remission of proteinuria in 3-8 days. Four of the six improved patients had other manifestations of food allergy including recurrent bronchitis, atopic dermatitis, and gastrointestinal disturbances.
Ferri et al stated that ' dietary macromolecular antigens can be involved in the pathogenesis of IgA nephropathy (IgAN), the effect of a low-antigen-content diet was evaluated in 21 patients with immunohistochemical findings of active IgAN. The diet was followed for a 14-24-week period in all cases the effects of the treatment were evaluated by clinical and serological parameters, and in 11 patients also by repeat renal biopsy. After dietetic therapy a significant reduction of urinary proteins was recorded in particular, heavy proteinuria present in 12 cases during the 6 months preceding the treatment, was markedly reduced or disappeared in 11.
Sato et al reported: "... that food antigens participate strongly in the pathogenesis of some patients with IgA nephropathy."
McCrory et al reported "... the occurrence of immune complex glomerulonephritis in a patient with eosinophilic gastroenteritis and food hypersensitivity. Renal biopsy revealed immune complex glomerulonephritis with BSA, immunoglobulins M and G and complement deposited focally in the glomerular basement membrane. With strict dietary limitation of identified causative antigens and prednisone therapy, CIC levels decreased to 16,000 micrograms/dl and serum BSA antibody hemagglutinating titer fell 32-fold over a period of 15 months. There was prompt symptomatic relief and amelioration of signs of nephritis. The patient was able to consume a diet normal in protein and caloric content, and statural catch-up growth occurred. Recognition of food antigens to which the patient was hypersensitive provided a rationale for the relief of the gastrointestinal disturbance, growth stunting, and renal disease.
The Canadian Pediatric Kidney Disease Reference Center
has related a specific kidney disease in children to ground beef. They have suggested that the hemolytic uremic syndrome is related to infection by common bacteria, E.Coli, which is spread in undercooked ground beef. A cluster of "hamburger disease" occurred, for example in Washington State in 1993 in people who ate undercooked beef contaminated by E.Coli from a fast-food chain. The bacteria can then spread from an infected person to people who have not eaten beef. Milk and other foods can also be contaminated. A hypersensitivity mechanism is triggered by the bacteria which then damages red blood cells and then the kidneys.
Alpha ENF: Often, full recovery involves a food holiday. Alpha ENF can be used as a completely absorbed, fully nourishing food-replacement. Alpha ENF can be used to supply nutrients that may be in short supply - such as amino acids, B vitamins, vitamins D and B12 and minerals such as calcium, magnesium, potassium, zinc.
We think that proteins in general are high-risk food components in kidney disease and we are concerned about the adverse effects of hydrolyzed proteins. Gluten, the proteins in wheat, rye, barley and oats are definitively excluded but other high risk proteins are albumin from eggs and milk, globulin and casein from milk, muscle proteins from meat, and soy proteins. When you begin diet revision you avoid eating all these proteins. Their use is postponed until full recovery has been achieved.. Proteins from vegetable sources appear to be better tolerated. Meal replacement formulas made with milk, egg or soy proteins should be avoided. All body-building protein powders are avoided.
Alpha ENF avoids all the protein problems by supplying the nutrient requirement with pure amino acids. The amino acid content of Alpha ENF will supplement or replace dietary protein. Alpha ENF can be added to fruit and vegetable juices to make complete meals of simple beverages and can be added to soups, or puddings after they have been cooked to increase their nutritive value. The most definitive rest and recovery technique is to take a Food Holiday.
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